A systematic review of active treatment options in patients with desmoid tumours
Identifieur interne : 002E08 ( Main/Exploration ); précédent : 002E07; suivant : 002E09A systematic review of active treatment options in patients with desmoid tumours
Auteurs : X. Yao [Canada] ; T. Corbett ; A. A. Gupta ; R. A. Kandel ; S. Verma ; J. Werier ; M. GhertSource :
- Current Oncology [ 1198-0052 ] ; 2014.
Abstract
We conducted a systematic review to determine the optimal treatment options in patients with desmoid tumours who have declined observational management.
A search was conducted of the
One systematic review and forty-six studies met the preplanned study selection criteria; data from twenty-eight articles were extracted and analyzed. For local control, three studies reported a statistically significant difference in favour of surgery plus radiotherapy (
In patients who have declined observational management, the local control rate was higher with surgery plus
Url:
DOI: 10.3747/co.21.1995
PubMed: 25089111
PubMed Central: 4117627
Affiliations:
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Le document en format XML
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">A systematic review of active treatment options in patients with desmoid tumours</title>
<author><name sortKey="Yao, X" sort="Yao, X" uniqKey="Yao X" first="X." last="Yao">X. Yao</name>
<affiliation wicri:level="4"><nlm:aff id="af1-conc-21-e613">Cancer Care Ontario’s Program in Evidence-Based Care, Department of Oncology, McMaster University, Hamilton, ON.</nlm:aff>
<orgName type="university">Université McMaster</orgName>
<country>Canada</country>
<placeName><settlement type="city">Hamilton (Ontario)</settlement>
<region type="state">Ontario</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Corbett, T" sort="Corbett, T" uniqKey="Corbett T" first="T." last="Corbett">T. Corbett</name>
<affiliation><nlm:aff id="af2-conc-21-e613">Division of Radiation Oncology, Juravinski Cancer Centre, Hamilton, ON.</nlm:aff>
<wicri:noCountry code="subfield">ON.</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Gupta, A A" sort="Gupta, A A" uniqKey="Gupta A" first="A. A." last="Gupta">A. A. Gupta</name>
<affiliation><nlm:aff id="af3-conc-21-e613">Division of Haematology/Oncology, Hospital for Sick Children, Toronto, ON.</nlm:aff>
<wicri:noCountry code="subfield">ON.</wicri:noCountry>
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<author><name sortKey="Kandel, R A" sort="Kandel, R A" uniqKey="Kandel R" first="R. A." last="Kandel">R. A. Kandel</name>
<affiliation><nlm:aff id="af4-conc-21-e613">Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, ON.</nlm:aff>
<wicri:noCountry code="subfield">ON.</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Verma, S" sort="Verma, S" uniqKey="Verma S" first="S." last="Verma">S. Verma</name>
<affiliation><nlm:aff id="af5-conc-21-e613">Department of Medical Oncology, The Ottawa Hospital Regional Cancer Centre, Ottawa, ON.</nlm:aff>
<wicri:noCountry code="subfield">ON.</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Werier, J" sort="Werier, J" uniqKey="Werier J" first="J." last="Werier">J. Werier</name>
<affiliation><nlm:aff id="af6-conc-21-e613">Department of Orthopaedic Surgery, The Ottawa Hospital Regional Cancer Centre, Ottawa, ON.</nlm:aff>
<wicri:noCountry code="subfield">ON.</wicri:noCountry>
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<series><title level="j">Current Oncology</title>
<idno type="ISSN">1198-0052</idno>
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<front><div type="abstract" xml:lang="en"><sec><title>Introduction</title>
<p>We conducted a systematic review to determine the optimal treatment options in patients with desmoid tumours who have declined observational management.</p>
</sec>
<sec><title>Methods</title>
<p>A search was conducted of the <sc>medline</sc>
and <sc>embase</sc>
databases (1990 to September 2012), the Cochrane Library, and relevant guideline Web sites and conference materials.</p>
</sec>
<sec><title>Results</title>
<p>One systematic review and forty-six studies met the preplanned study selection criteria; data from twenty-eight articles were extracted and analyzed. For local control, three studies reported a statistically significant difference in favour of surgery plus radiotherapy (<sc>rt</sc>
) compared with surgery alone, and one study did not; two studies reported the lack of a statistical difference between surgery plus <sc>rt</sc>
and <sc>rt</sc>
alone in maintaining local control. Multivariate risk factors for local recurrence included positive surgical margins and young patient age. Single-agent imatinib led to a progression-free survival rate of 55% at 2 years and 58% at 3 years. Methotrexate plus vinblastine led to a progression-free survival rate of 67% at 10 years. Significant toxicities were reported for all treatment modalities, including surgical morbidity, and <sc>rt</sc>
- and chemotherapy-related toxicities.</p>
</sec>
<sec><title>Conclusions</title>
<p>In patients who have declined observational management, the local control rate was higher with surgery plus <sc>rt</sc>
than with surgery alone. However, the additional <sc>rt</sc>
-related complications should be considered in treatment decision-making. Surgery, <sc>rt</sc>
, and systemic therapy are all reasonable treatment options for patients with desmoid tumours.</p>
</sec>
</div>
</front>
</TEI>
<affiliations><list><country><li>Canada</li>
</country>
<region><li>Ontario</li>
</region>
<settlement><li>Hamilton (Ontario)</li>
</settlement>
<orgName><li>Université McMaster</li>
</orgName>
</list>
<tree><noCountry><name sortKey="Corbett, T" sort="Corbett, T" uniqKey="Corbett T" first="T." last="Corbett">T. Corbett</name>
<name sortKey="Ghert, M" sort="Ghert, M" uniqKey="Ghert M" first="M." last="Ghert">M. Ghert</name>
<name sortKey="Gupta, A A" sort="Gupta, A A" uniqKey="Gupta A" first="A. A." last="Gupta">A. A. Gupta</name>
<name sortKey="Kandel, R A" sort="Kandel, R A" uniqKey="Kandel R" first="R. A." last="Kandel">R. A. Kandel</name>
<name sortKey="Verma, S" sort="Verma, S" uniqKey="Verma S" first="S." last="Verma">S. Verma</name>
<name sortKey="Werier, J" sort="Werier, J" uniqKey="Werier J" first="J." last="Werier">J. Werier</name>
</noCountry>
<country name="Canada"><region name="Ontario"><name sortKey="Yao, X" sort="Yao, X" uniqKey="Yao X" first="X." last="Yao">X. Yao</name>
</region>
</country>
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